DataGridView1.CurrentCell = DataGridView1.Item(1, 5)
or
DataGridView1.CurrentCell = DataGridView1.Item("ColumnName", 5)
and you can directly focus with Editing by:
dataGridView1.BeginEdit(true)
DataGridView1.CurrentCell = DataGridView1.Item(1, 5)
DataGridView1.CurrentCell = DataGridView1.Item("ColumnName", 5)
dataGridView1.BeginEdit(true)